Leen Van den Neste has been a member of the Board of Directors of vdk bank since 2008, where she effectively joined on 1 September 2011. On 1 April 2012, she became chairwoman of the executive committee.

She has worked successively for KPMG and Groep Arco. She is also a member of the board of directors of Retail Estates and a director at AA Gent football club, as well as a member of the board of directors of FPIM. Leen Van den Neste is also a board member of the financial employers' organisation Febelfin.

Leen Van den Neste graduated in law from the State University of Ghent and later obtained a special licence in accountancy from the Vlerick School for Management in Ghent.